What term describes a strong uneasiness caused by a sense of guilt?

The term that describes a strong uneasiness caused by a sense of guilt is "compunction." This word specifically refers to the feeling of guilt or moral scruple that arises when one knows they have done something wrong. It not only suggests a feeling of unease but emphasizes the internal conflict and discomfort that accompanies an awareness of guilt. Compunction tends to be linked to a moment of realization regarding one's actions and their moral implications, highlighting both the emotional pain and the sense of responsibility inherent in the experience.

In contrast, disquiet refers more generally to a lack of peace or calm, without the specific connotation of guilt. Regret is a broader term that expresses sorrow or disappointment over something that has happened or been done, but it doesn't necessarily include the moral implications tied to compunction. Remorse, while closely related, typically encompasses a deeper, more profound sense of guilt and sorrow for one's actions, often accompanied by a wish to make amends, which can differ from the immediate uneasiness characterized by compunction.